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The degree of substitution (DS) is a critical parameter in HPMC synthesis. It refers to the average number of hydroxyl groups on the cellulose molecule that are replaced by hydroxypropyl and methyl groups. A higher DS generally leads to increased solubility in water and enhanced viscosity in solution, making the polymer more effective for various applications. Manufacturers often tailor the DS to suit specific requirements, allowing for a range of HPMC products with differing properties.
hpmc synthesis
